PDBe 4tnb

X-ray diffraction
2.11Å resolution

Crystal Structure of G Protein-Coupled Receptor Kinase 5 in Complex with Sangivamycin

Released:

Function and Biology Details

Reaction catalysed:
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G protein-coupled receptor kinase 5 Chain: A
Molecule details ›
Chain: A
Length: 590 amino acids
Theoretical weight: 67.94 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P34947 (Residues: 1-590; Coverage: 100%)
Gene names: GPRK5, GRK5
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X6A
Spacegroup: P43212
Unit cell:
a: 62.676Å b: 62.676Å c: 292.201Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.17 0.232
Expression system: Spodoptera frugiperda