4tn3

X-ray diffraction
3.2Å resolution

Structure of the BBox-Coiled-coil region of Rhesus Trim5alpha

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endolysin; RING-type E3 ubiquitin transferase TRIM5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 400 amino acids
Theoretical weight: 46.33 KDa
Source organisms: Expression system: Escherichia coli
UniProt:
  • Canonical: G9MAP5 (Residues: 88-304; Coverage: 46%)
  • Canonical: P00720 (Residues: 2-164; Coverage: 99%)
Gene names: E, TRIMCyp
Sequence domains:
Structure domains: Lysozyme

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2
Unit cell:
a: 124.118Å b: 59.745Å c: 146.962Å
α: 90° β: 94.77° γ: 90°
R-values:
R R work R free
0.261 0.258 0.316
Expression system: Escherichia coli