4tmf

X-ray diffraction
2.05Å resolution

Crystal structure of human CD38 in complex with hydrolysed compound JMS713

Released:

Function and Biology Details

Reactions catalysed:
(1a) NAD(+) = cyclic ADP-ribose + nicotinamide
(1a) NADP(+) = 2'-phospho-cyclic ADP-ribose + nicotinamide
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.81 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P28907 (Residues: 50-300; Coverage: 84%)
  • Best match: P28907-2 (Residues: 50-121)
Gene name: CD38
Sequence domains: ADP-ribosyl cyclase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 41.69Å b: 54.128Å c: 63.319Å
α: 108.58° β: 90.98° γ: 93.98°
R-values:
R R work R free
0.2 0.198 0.227
Expression system: Komagataella pastoris