› 4tlt

X-ray diffraction
1.7Å resolution

Crystal structure of human transthyretin

Released:
DOI: 10.2210/pdb4tlt/pdb
PDB entry 4tlt coloured by chain, front view.
PDB entry 4tlt coloured by chain, side view.
PDB entry 4tlt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Uncovering the Mechanism of Aggregation of Human Transthyretin.
Saelices L, Johnson LM, Liang WY, Sawaya MR, Cascio D, Ruchala P, Whitelegge J, Jiang L, Riek R, Eisenberg DS
J Biol Chem 290 28932-43 (2015)
PMID: 26459562

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136168 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B
Molecule details ›
Chains: A, B
Length: 125 amino acids
Theoretical weight: 13.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02766 (Residues: 29-147; Coverage: 94%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

1 bound ligand:
Ligand MG 2 x MG
1 modified residue:
Ligand OCS 2 x OCS

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P21212
Unit cell:
a: 41.24Å b: 84.24Å c: 63.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

The activities of amyloids from a structural perspective.
Riek et al. (2016)
18 more

9 mentions without citation

Transthyretin Stabilization: An Emerging Strategy for the Treatment of Alzheimer's Disease?
Saponaro et al. (2020)
8 more