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Structure of the SNX17 FERM domain bound to the second NPxF motif of KRIT1

X-ray diffraction
3Å resolution
PDB entry 4tkn coloured by chain, front view.
PDB entry 4tkn coloured by chain, side view.
PDB entry 4tkn coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Sorting nexin-17 and Krev interaction trapped protein 1
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Multimeric state: hetero dimer
Accessible surface area: 14305.81 Å2
Buried surface area: 1102.92 Å2
Dissociation area: 551.46 Å2
Dissociation energy (ΔGdiss): 6.6 kcal/mol
Dissociation entropy (TΔSdiss): 7.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126336
Assembly 2
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Assembly Name: Sorting nexin-17 and Krev interaction trapped protein 1
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Multimeric state: hetero dimer
Accessible surface area: 13814.94 Å2
Buried surface area: 1042.26 Å2
Dissociation area: 521.13 Å2
Dissociation energy (ΔGdiss): 7.73 kcal/mol
Dissociation entropy (TΔSdiss): 7.04 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126336
Assembly 3
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Assembly Name: Sorting nexin-17 and Krev interaction trapped protein 1
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Multimeric state: hetero dimer
Accessible surface area: 14814.69 Å2
Buried surface area: 1083.77 Å2
Dissociation area: 541.89 Å2
Dissociation energy (ΔGdiss): 6.61 kcal/mol
Dissociation entropy (TΔSdiss): 7.08 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126336

Macromolecules

Sorting nexin-17
Chains: A, B, C
Length: 286 amino acids
Theoretical weight: 32.47 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15036 (Residues: 108-391; Coverage: 60%)
Gene names: KIAA0064, SNX17
Pfam:
InterPro:
CATH:
Sorting nexin-17 in PDB entry 4tkn, assembly 1, front view.
Sorting nexin-17 in PDB entry 4tkn, assembly 1, side view.
Sorting nexin-17 in PDB entry 4tkn, assembly 1, top view.
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Krev interaction trapped protein 1
Chains: D, E, F
Length: 19 amino acids
Theoretical weight: 1.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O00522 (Residues: 225-237; Coverage: 2%)
Gene names: CCM1, KRIT1
Krev interaction trapped protein 1 in PDB entry 4tkn, assembly 1, front view.
Krev interaction trapped protein 1 in PDB entry 4tkn, assembly 1, side view.
Krev interaction trapped protein 1 in PDB entry 4tkn, assembly 1, top view.
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