X-ray diffraction
1.48Å resolution

ERK2 R65S mutant complexed with AMP-PNP

Source organism: Rattus norvegicus
Entry authors: Livnah O, Karamansha Y, Tzarum N

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitogen-activated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 358 amino acids
Theoretical weight: 41.26 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
  • Canonical: P63086 (Residues: 1-358; Coverage: 100%)
Gene names: Erk2, Mapk, Mapk1, Prkm1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 48.813Å b: 70.438Å c: 60.082Å
α: 90° β: 109.28° γ: 90°
R R work R free
0.199 0.196 0.239
Expression system: Escherichia coli