Structure analysis

Structure of Mycobacterium tuberculosis NadD in complex with NADP

X-ray diffraction
1.84Å resolution
Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 2
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Multimeric state: monomeric

Binding statistics and energies are not available for this assembly
Assembly 3
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Multimeric state: homo tetramer
Accessible surface area: 29000 Å2
Buried surface area: 11000 Å2
Dissociation area: 1,800 Å2
Dissociation energy (ΔGdiss): 14 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -90 kcal/mol
Symmetry number: 4
Assembly 4
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Multimeric state: homo dimer

Binding statistics and energies are not available for this assembly
Assembly 5
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Multimeric state: homo dimer
Accessible surface area: 15800 Å2
Buried surface area: 4000 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): 2 kcal/mol
Dissociation entropy (TΔSdiss): 12 kcal/mol
Interface energy (ΔGint): -28 kcal/mol
Symmetry number: 2
Assembly 6
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Multimeric state: homo dimer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.35 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WJJ5 (Residues: 1-192; Coverage: 91%)
Gene names: MTCY428.26, Rv2421c, nadD
Pfam: Cytidylyltransferase-like
InterPro:
CATH: HUPs

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