Function and Biology

Crystal Structure of HLTF HIRAN Domain bound to DNA

Source organisms:
Biochemical function: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Biological process: not assigned
Cellular component: not assigned

EC 2.3.2.27: RING-type E3 ubiquitin transferase

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Systematic name:
[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine:[acceptor protein]-L-lysine ubiquitin transferase (isopeptide bond-forming; RING-type)
Alternative Name(s):
  • RING E3 ligase
  • Ubiquitin transferase RING E3

GO terms

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF08797
Domain description: HIRAN domain
Occurring in:
  1. Helicase-like transcription factor
The deposited structure of PDB entry 4s0n contains 4 copies of Pfam domain PF08797 (HIRAN domain) in Helicase-like transcription factor. Showing 1 copy in chain D.

InterPro InterPro annotation
IPR014905
Domain description: HIRAN domain
Occurring in:
  1. Helicase-like transcription factor