4ryx

X-ray diffraction
2Å resolution

Crystal structure of RPE65 in complex with emixustat and palmitate, P6522 crystal form

Released:
Source organism: Bos taurus
Entry authors: Kiser PD, Palczewski K

Function and Biology Details

Reactions catalysed:
An all-trans-retinyl ester + H(2)O = 11-cis-retinol + a fatty acid
Lutein = meso-zeaxanthin
Biochemical function:
Biological process:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinoid isomerohydrolase Chain: A
Molecule details ›
Chain: A
Length: 533 amino acids
Theoretical weight: 61.04 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q28175 (Residues: 1-533; Coverage: 100%)
Gene name: RPE65
Sequence domains: Retinal pigment epithelial membrane protein

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6522
Unit cell:
a: 177.766Å b: 177.766Å c: 86.58Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.167 0.164 0.21