4rxp

X-ray diffraction
2.1Å resolution

The structure of GTP-dATP-bound SAMHD1

Released:
Source organism: Homo sapiens
Entry authors: Zhu CF, Wei W, Peng X, Dong YH, Gong Y, Yu XF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 539 amino acids
Theoretical weight: 62.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 109-626; Coverage: 83%)
Gene names: MOP5, SAMHD1
Sequence domains: HD domain
Structure domains: Hypothetical protein af1432

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: C2
Unit cell:
a: 151.154Å b: 108.094Å c: 92.425Å
α: 90° β: 122.98° γ: 90°
R-values:
R R work R free
0.182 0.18 0.208
Expression system: Escherichia coli