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The structure of GTP-bound SAMHD1

X-ray diffraction
2.6Å resolution
PDB entry 4rxo coloured by chain, front view.
PDB entry 4rxo coloured by chain, side view.
PDB entry 4rxo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
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Multimeric state: homo dimer
Accessible surface area: 37984.71 Å2
Buried surface area: 5871.9 Å2
Dissociation area: 2,154.79 Å2
Dissociation energy (ΔGdiss): 4.1 kcal/mol
Dissociation entropy (TΔSdiss): 14.88 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195221
Assembly 2
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Assembly Name: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
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Multimeric state: homo dimer
Accessible surface area: 37706.43 Å2
Buried surface area: 5864.87 Å2
Dissociation area: 2,149.12 Å2
Dissociation energy (ΔGdiss): 5.1 kcal/mol
Dissociation entropy (TΔSdiss): 14.87 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-195221

Macromolecules

Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
Chains: A, B, C, D
Length: 539 amino acids
Theoretical weight: 62.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y3Z3 (Residues: 109-626; Coverage: 83%)
Gene names: MOP5, SAMHD1
Pfam: HD domain
InterPro:
CATH: Hypothetical protein af1432
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 4rxo, assembly 1, front view.
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 4rxo, assembly 1, side view.
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 in PDB entry 4rxo, assembly 1, top view.
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