X-ray diffraction
1.14Å resolution

Crystal structure of human Carbonic Anhydrase II in complex with 4-propoxybenzenesulfonamide

Source organism: Homo sapiens
Entry authors: Pinard MA, Mckenna R

Function and Biology Details

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Carbonic anhydrase 2 Chain: A
Molecule details ›
Chain: A
Length: 260 amino acids
Theoretical weight: 29.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P00918 (Residues: 1-260; Coverage: 100%)
Gene name: CA2
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Alpha carbonic anhydrase

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P21
Unit cell:
a: 42.271Å b: 41.107Å c: 71.663Å
α: 90° β: 104.29° γ: 90°
R R work R free
0.202 0.201 0.216
Expression system: Escherichia coli