4rt7

X-ray diffraction
3.1Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor-type tyrosine-protein kinase FLT3 Chain: A
Molecule details ›
Chain: A
Length: 415 amino acids
Theoretical weight: 48.2 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P36888 (Residues: 564-958; Coverage: 41%)
Gene names: CD135, FLK2, FLT3, STK1
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P3221
Unit cell:
a: 78.88Å b: 78.88Å c: 138.36Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.224 0.218 0.268
Expression system: Spodoptera frugiperda