PDBe 4rs6

X-ray diffraction
2.6Å resolution

Crystal structure of the C domain of Polo like Kinase II in Homo Sapiens

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the polo-box domain of polo-like kinase 2.
Biochem. Biophys. Res. Commun. 456 780-4 (2015)
PMID: 25511705

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 242 amino acids
Theoretical weight: 27.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NYY3 (Residues: 451-685; Coverage: 34%)
Gene names: PLK2, SNK
Sequence domains: POLO box duplicated region
Structure domains: POLO box domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: I23
Unit cell:
a: 153.075Å b: 153.075Å c: 153.075Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.189 0.186 0.247
Expression system: Escherichia coli BL21(DE3)