PDBe 4rs1

X-ray diffraction
2.68Å resolution

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Chain: B
Molecule details ›
Chain: B
Length: 281 amino acids
Theoretical weight: 32.87 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15509 (Residues: 35-315; Coverage: 74%)
  • Best match: P15509-8 (Residues: 1-182)
Gene names: CSF2R, CSF2RA, CSF2RY
Sequence domains:
Granulocyte-macrophage colony-stimulating factor Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04141 (Residues: 31-142; Coverage: 88%)
Gene names: CSF2, GMCSF
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Unit cell:
a: 49.801Å b: 77.169Å c: 117.741Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.287
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli