X-ray diffraction
2.25Å resolution

Crystal structure of Micobacterium tuberculosis UDP-Galactopyranose mutase in complex with tetrafluorinated substrate analog UDP-F4-Galp


Function and Biology Details

Reaction catalysed:
UDP-alpha-D-galactopyranose = UDP-alpha-D-galactofuranose
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
UDP-galactopyranose mutase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 399 amino acids
Theoretical weight: 45.93 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P9WIQ1 (Residues: 1-399; Coverage: 100%)
Gene names: Rv3809c, glf
Sequence domains:
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments

Cofactor: Ligand FAD 3 x FAD
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: C2
Unit cell:
a: 171.29Å b: 98.29Å c: 100.52Å
α: 90° β: 109.94° γ: 90°
R R work R free
0.22 0.218 0.26
Expression system: Escherichia coli BL21(DE3)