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Crystal structure of homoserine kinase from Yersinia pestis Nepal516, NYSGRC target 032715

X-ray diffraction
2.3Å resolution
PDB entry 4rpf coloured by chain, front view.
PDB entry 4rpf coloured by chain, side view.
PDB entry 4rpf coloured by chain, top view.
Source organism: Yersinia pestis Nepal516
Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Homoserine kinase
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Multimeric state: monomeric
Accessible surface area: 13330.29 Å2
Buried surface area: 415.17 Å2
Dissociation area: 207.58 Å2
Dissociation energy (ΔGdiss): 1.63 kcal/mol
Dissociation entropy (TΔSdiss): 2.78 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172781
Assembly 2
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Assembly Name: Homoserine kinase
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Multimeric state: monomeric
Accessible surface area: 13300.77 Å2
Buried surface area: 417.58 Å2
Dissociation area: 208.79 Å2
Dissociation energy (ΔGdiss): 1.73 kcal/mol
Dissociation entropy (TΔSdiss): 2.81 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172781
Assembly 3
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Assembly Name: Homoserine kinase
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Multimeric state: monomeric
Accessible surface area: 13214.69 Å2
Buried surface area: 419.98 Å2
Dissociation area: 209.99 Å2
Dissociation energy (ΔGdiss): 0.62 kcal/mol
Dissociation entropy (TΔSdiss): 2.8 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-172781
Assembly 4
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Assembly Name: Homoserine kinase
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Multimeric state: homo dimer
Accessible surface area: 23564.84 Å2
Buried surface area: 3898.98 Å2
Dissociation area: 1,533.11 Å2
Dissociation energy (ΔGdiss): 6.66 kcal/mol
Dissociation entropy (TΔSdiss): 13.54 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172782
Assembly 5
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Assembly Name: Homoserine kinase
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Multimeric state: homo dimer
Accessible surface area: 23437.84 Å2
Buried surface area: 3845.47 Å2
Dissociation area: 1,502.85 Å2
Dissociation energy (ΔGdiss): 6.92 kcal/mol
Dissociation entropy (TΔSdiss): 13.53 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-172782

Macromolecules

Homoserine kinase
Chains: A, B, C
Length: 310 amino acids
Theoretical weight: 33.35 KDa
Source organism: Yersinia pestis Nepal516
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q1CMW6 (Residues: 1-309; Coverage: 100%)
Gene names: YP516_0338, YPN_0332, thrB
Pfam:
InterPro:
CATH:
Homoserine kinase in PDB entry 4rpf, assembly 1, front view.
Homoserine kinase in PDB entry 4rpf, assembly 1, side view.
Homoserine kinase in PDB entry 4rpf, assembly 1, top view.
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