› 4rp7

X-ray diffraction
1.58Å resolution

Structure of the amyloid-forming segment TIITLE from p53 (residues 253-258)

Released:
DOI: 10.2210/pdb4rp7/pdb
PDB 4rp7 coloured by chain and viewed from the front.
PDB 4rp7 coloured by chain and viewed from the side.
PDB 4rp7 coloured by chain and viewed from the top.
Source organism: Homo sapiens
Entry authors: Soriaga AB, Soragni A, Eisenberg D

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cellular tumor antigen p53 Chain: Z
Molecule details ›
Chain: Z
Length: 6 amino acids
Theoretical weight: 689 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 253-258; Coverage: 2%)
Gene names: P53, TP53

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: C2
Unit cell:
a: 43.018Å b: 4.849Å c: 19.774Å
α: 90° β: 92.12° γ: 90°
R-values:
R R work R free
0.167 0.164 0.192
Expression system: Not provided

Quick links

Citations

59 review citations

A role for bioinorganic chemistry in the reactivation of mutant p53 in cancer.
Miller et al. (2022)
58 more