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Crystal Structure of the L27 domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster (space group P21)

X-ray diffraction
1.65Å resolution
PDB entry 4rp5 coloured by chain, front view.
PDB entry 4rp5 coloured by chain, side view.
PDB entry 4rp5 coloured by chain, top view.
Source organism: Drosophila melanogaster
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Disks large 1 tumor suppressor protein
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Multimeric state: homo dimer
Accessible surface area: 11956.19 Å2
Buried surface area: 5105.53 Å2
Dissociation area: 2,504.44 Å2
Dissociation energy (ΔGdiss): 35.61 kcal/mol
Dissociation entropy (TΔSdiss): 12.35 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151872

Macromolecules

Disks large 1 tumor suppressor protein
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.48 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31007 (Residues: 1-97; Coverage: 10%)
Gene names: CG1725, dlg1, l(1)dlg1
Pfam: L27_1
InterPro:
Disks large 1 tumor suppressor protein in PDB entry 4rp5, assembly 1, front view.
Disks large 1 tumor suppressor protein in PDB entry 4rp5, assembly 1, side view.
Disks large 1 tumor suppressor protein in PDB entry 4rp5, assembly 1, top view.
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