› 4rp3

X-ray diffraction
1.36Å resolution

Crystal Structure of the L27 Domain of Discs Large 1 (target ID NYSGRC-010766) from Drosophila melanogaster bound to a potassium ion (space group P212121)

Released:
DOI: 10.2210/pdb4rp3/pdb
PDB 4rp3 coloured by chain and viewed from the front.
PDB 4rp3 coloured by chain and viewed from the side.
PDB 4rp3 coloured by chain and viewed from the top.
Source organism: Drosophila melanogaster
Primary publication:
Structures of the L27 Domain of Disc Large Homologue 1 Protein Illustrate a Self-Assembly Module.
Ghosh A, Ramagopal UA, Bonanno JB, Brenowitz M, Almo SC
Biochemistry (2018)
PMID: 29261291

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Disks large 1 tumor suppressor protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.43 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31007 (Residues: 1-97; Coverage: 10%)
Gene names: CG1725, dlg1, l(1)dlg1
Sequence domains: L27_1

Ligands and Environments

3 bound ligands:
Ligand K 1 x K
Ligand FMT 2 x FMT
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P212121
Unit cell:
a: 47.979Å b: 57.571Å c: 64.529Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.15 0.147 0.206
Expression system: Escherichia coli BL21(DE3)

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Citations

3 review citations

The Scribble Complex PDZ Proteins in Immune Cell Polarities.
Barreda et al. (2020)
2 more