› 4rmc

X-ray diffraction
2.7Å resolution

Crystal Structure of human retinoid X receptor alpha-ligand binding domain complex with 9cUAB76 and the coactivator peptide GRIP-1

Released:
DOI: 10.2210/pdb4rmc/pdb
PDB 4rmc coloured by chain and viewed from the front.
PDB 4rmc coloured by chain and viewed from the side.
PDB 4rmc coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
Atigadda VR, Xia G, Deshpande A, Wu L, Kedishvili N, Smith CD, Krontiras H, Bland KI, Grubbs CJ, Brouillette WJ, Muccio DD
J Med Chem 58 7763-74 (2015)
PMID: 26331194

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 228-458; Coverage: 50%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand 3SV 1 x 3SV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P43212
Unit cell:
a: 65.846Å b: 65.846Å c: 112.563Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.265 0.187 0.265
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

4 review citations

A review of the molecular design and biological activities of RXR agonists.
de Almeida et al. (2019)
3 more

1 mention without citation

Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers.
Atigadda et al. (2015)