› 4rly

X-ray diffraction
2.5Å resolution

Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain

Released:
DOI: 10.2210/pdb4rly/pdb
PDB 4rly coloured by chain and viewed from the front.
PDB 4rly coloured by chain and viewed from the side.
PDB 4rly coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Structural basis of diverse membrane target recognitions by ankyrins.
Wang C, Wei Z, Chen K, Ye F, Yu C, Bennett V, Zhang M
OpenAccess logo Elife 3 (2014)
PMID: 25383926

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ankyrin-2; Sodium channel protein type 2 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99250 (Residues: 1102-1120; Coverage: 1%)
  • Canonical: Q01484 (Residues: 28-318; Coverage: 7%)
Gene names: ANK2, ANKB, NAC2, SCN2A, SCN2A1, SCN2A2
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:
Ligand SO4 7 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P4222
Unit cell:
a: 102.295Å b: 102.295Å c: 106.008Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Ankyrins: Roles in synaptic biology and pathology.
Smith et al. (2018)
4 more

1 mention without citation

Structural basis for the membrane association of ankyrinG via palmitoylation.
Fujiwara et al. (2016)