X-ray diffraction
2.5Å resolution

Crystal Structure of AnkB Ankyrin Repeats (R1-R9) in Complex with Nav1.2 Ankyrin Binding Domain


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Ankyrin-2; Sodium channel protein type 2 subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 34.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: Q99250 (Residues: 1102-1120; Coverage: 1%)
  • Canonical: Q01484 (Residues: 28-318; Coverage: 7%)
Gene names: ANK2, ANKB, NAC2, SCN2A, SCN2A1, SCN2A2
Sequence domains:
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P4222
Unit cell:
a: 102.295Å b: 102.295Å c: 106.008Å
α: 90° β: 90° γ: 90°
R R work R free
0.19 0.188 0.238
Expression system: Escherichia coli BL21(DE3)