PDBe 4rlo

X-ray diffraction
2.53Å resolution

Human p70s6k1 with ruthenium-based inhibitor EM5


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Ribosomal protein S6 kinase beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 288 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P23443 (Residues: 85-372; Coverage: 55%)
Gene names: RPS6KB1, STK14A
Sequence domains: Protein kinase domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 78.515Å b: 62.882Å c: 86.718Å
α: 90° β: 94.02° γ: 90°
R R work R free
0.193 0.192 0.222
Expression system: Spodoptera frugiperda