4ri5

X-ray diffraction
1.26Å resolution

Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 306 amino acids
Theoretical weight: 34.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P26045 (Residues: 628-909; Coverage: 31%)
Gene names: PTPH1, PTPN3
Sequence domains: Protein-tyrosine phosphatase
Structure domains: Protein tyrosine phosphatase superfamily

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL15A1
Spacegroup: C2221
Unit cell:
a: 95.162Å b: 96.071Å c: 141.722Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.16 0.159 0.173
Expression system: Escherichia coli