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Crystal structure of BTK kinase domain complexed with 2-[8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)-2-pyridyl]amino]-6-oxo-3-pyridyl]phenyl]-1-oxo-3,4-dihydroisoquinolin-6-yl]-2-methyl-propanenitrile

X-ray diffraction
2.5Å resolution
PDB entry 4rg0 coloured by chain, front view.
PDB entry 4rg0 coloured by chain, side view.
PDB entry 4rg0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein kinase BTK
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Multimeric state: monomeric
Accessible surface area: 12544.31 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-170299

Macromolecules

Tyrosine-protein kinase BTK
Chain: A
Length: 283 amino acids
Theoretical weight: 32.52 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q06187 (Residues: 378-659; Coverage: 43%)
Gene names: AGMX1, ATK, BPK, BTK
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Tyrosine-protein kinase BTK in PDB entry 4rg0, assembly 1, front view.
Tyrosine-protein kinase BTK in PDB entry 4rg0, assembly 1, side view.
Tyrosine-protein kinase BTK in PDB entry 4rg0, assembly 1, top view.
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