4rdu

X-ray diffraction
1.85Å resolution

Crystal structure of a distal-less homeobox protein 5 (Dlx5) from Homo sapiens at 1.85 A resolution

Released:
Entry authors: Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
Homeobox protein DLX-5 Chains: A, D
Molecule details ›
Chains: A, D
Length: 65 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P56178 (Residues: 135-198; Coverage: 22%)
Gene name: DLX5
Sequence domains: Homeodomain
Structure domains: Homeodomain-like
(DC)(DG)(DA)(DC)(DT)(DA)(DA)(DT)(DT)(DA)(DG)(DT)(DC)(DG) Chains: B, C, E, F
Molecule details ›
Chains: B, C, E, F
Length: 14 nucleotides
Theoretical weight: 4.28 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL14-1
Spacegroup: P1
Unit cell:
a: 34.182Å b: 42.913Å c: 56.104Å
α: 84.13° β: 77.33° γ: 67.13°
R-values:
R R work R free
0.185 0.183 0.225
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided