4rca

X-ray diffraction
2.99Å resolution

Crystal structure of human PTPdelta and human Slitrk1 complex

Released:

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Receptor-type tyrosine-protein phosphatase delta Chain: A
Molecule details ›
Chain: A
Length: 308 amino acids
Theoretical weight: 33.85 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P23468 (Residues: 21-322; Coverage: 16%)
Gene name: PTPRD
Sequence domains:
Structure domains: Immunoglobulins
SLIT and NTRK-like protein 1 Chain: B
Molecule details ›
Chain: B
Length: 251 amino acids
Theoretical weight: 28.66 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q96PX8 (Residues: 20-264; Coverage: 36%)
Gene names: KIAA1910, LRRC12, SLITRK1, UNQ233/PRO266
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 7A (6B, 6C1)
Spacegroup: P21
Unit cell:
a: 76.981Å b: 60.195Å c: 83.679Å
α: 90° β: 102.19° γ: 90°
R-values:
R R work R free
0.263 0.262 0.269
Expression system: Spodoptera frugiperda