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Crystal structure of Rv1600 encoded aminotransferase from Mycobacterium tuberculosis

Source organism: Mycobacterium tuberculosis H37Rv
Biochemical function: pyridoxal phosphate binding
Biological process: biosynthetic process
Cellular component: peptidoglycan-based cell wall

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EC 2.6.1.9: Histidinol-phosphate transaminase

Reaction catalysed:
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
Systematic name:
L-histidinol-phosphate:2-oxoglutarate aminotransferase
Alternative Name(s):
  • Glutamic-imidazoleacetol phosphate transaminase
  • Histidine:imidazoleacetol phosphate transaminase
  • Histidinol phosphate aminotransferase
  • Histidinol-phosphate aminotransferase
  • IAP transaminase
  • Imidazole acetol-phosphate transaminase
  • Imidazoleacetol phosphate transaminase
  • Imidazolylacetolphosphate aminotransferase
  • Imidazolylacetolphosphate transaminase
  • L-histidinol phosphate aminotransferase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF00155
Domain description: Aminotransferase class I and II
Occurring in:
  1. Histidinol-phosphate aminotransferase
The deposited structure of PDB entry 4rae contains 2 copies of Pfam domain PF00155 (Aminotransferase class I and II) in Histidinol-phosphate aminotransferase. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR005861
Domain description: Histidinol-phosphate aminotransferase family
Occurring in:
  1. Histidinol-phosphate aminotransferase
IPR001917
Domain description: Aminotransferase, class-II, pyridoxal-phosphate binding site
Occurring in:
  1. Histidinol-phosphate aminotransferase
IPR015421
Domain description: Pyridoxal phosphate-dependent transferase, major domain
Occurring in:
  1. Histidinol-phosphate aminotransferase
IPR004839
Domain description: Aminotransferase, class I/classII
Occurring in:
  1. Histidinol-phosphate aminotransferase
IPR015424
Domain description: Pyridoxal phosphate-dependent transferase
Occurring in:
  1. Histidinol-phosphate aminotransferase
IPR015422
Domain description: Pyridoxal phosphate-dependent transferase, small domain
Occurring in:
  1. Histidinol-phosphate aminotransferase

Structure domains

CATH CATH domains
3.90.1150.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Aspartate Aminotransferase, domain 1
Homology: Aspartate Aminotransferase, domain 1
Occurring in:
  1. Histidinol-phosphate aminotransferase
The deposited structure of PDB entry 4rae contains 2 copies of CATH domain 3.90.1150.10 (Aspartate Aminotransferase, domain 1) in Histidinol-phosphate aminotransferase. Showing 1 copy in chain A.
3.40.640.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Aspartate Aminotransferase; domain 2
Homology: Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Occurring in:
  1. Histidinol-phosphate aminotransferase
The deposited structure of PDB entry 4rae contains 2 copies of CATH domain 3.40.640.10 (Aspartate Aminotransferase; domain 2) in Histidinol-phosphate aminotransferase. Showing 1 copy in chain A.

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