4rae

X-ray diffraction
2.59Å resolution

Crystal structure of Rv1600 encoded aminotransferase from Mycobacterium tuberculosis

Released:
Entry authors: Nasir N, Anant A, Vyas R, Biswal BK

Function and Biology Details

Reaction catalysed:
L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histidinol-phosphate aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 42.28 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Mycolicibacterium smegmatis
UniProt:
  • Canonical: P9WML7 (Residues: 1-380; Coverage: 100%)
Gene names: MTCY336.04c, Rv1600, hisC, hisC1
Sequence domains: Aminotransferase class I and II
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E+ DW
Spacegroup: P3221
Unit cell:
a: 159.937Å b: 159.937Å c: 110.317Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.239 0.279
Expression system: Mycolicibacterium smegmatis