› 4r9v

X-ray diffraction
2.3Å resolution

Crystal structure of sialyltransferase from photobacterium damselae, residues 113-497 corresponding to the gt-b domain

Released:
DOI: 10.2210/pdb4r9v/pdb
PDB 4r9v coloured by chain and viewed from the front.
PDB 4r9v coloured by chain and viewed from the side.
PDB 4r9v coloured by chain and viewed from the top.
Source organism: Photobacterium damselae
Primary publication:
Crystal structures of sialyltransferase from Photobacterium damselae.
Huynh N, Li Y, Yu H, Huang S, Lau K, Chen X, Fisher AJ
FEBS Lett 588 4720-9 (2014)
PMID: 25451227

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialyltransferase 0160 Chain: A
Molecule details ›
Chain: A
Length: 406 amino acids
Theoretical weight: 46.12 KDa
Source organism: Photobacterium damselae
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O66375 (Residues: 113-497; Coverage: 57%)
Gene name: bst
Sequence domains: Sialyltransferase PMO188
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: C2
Unit cell:
a: 95.444Å b: 56.523Å c: 87.375Å
α: 90° β: 119.95° γ: 90°
R-values:
R R work R free
0.187 0.184 0.248
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities.
Szabo et al. (2017)
1 more

1 mention without citation

Crystal structures of sialyltransferase from Photobacterium damselae.
Huynh et al. (2014)