› 4r7d

X-ray diffraction
2.75Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: A, C, E, G, I, K, M, O
Molecule details ›
Chains: A, C, E, G, I, K, M, O
Length: 225 amino acids
Theoretical weight: 24.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: A0A0M3KKW6 (Residues: 1-225; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins
Fab Hu 15C1 Light chain Chains: B, D, F, H, J, L, N, P
Molecule details ›
Chains: B, D, F, H, J, L, N, P
Length: 214 amino acids
Theoretical weight: 23.47 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 101.82Å b: 82.51Å c: 261.57Å
α: 90° β: 101.21° γ: 90°
R-values:
R R work R free
0.178 0.177 0.209
Expression system: Cricetulus griseus

Quick links

Citations

1 review citation

Monoclonal Antibody to CD14, TLR4, or CD11b: Impact of Epitope and Isotype Specificity on ROS Generation by Human Granulocytes and Monocytes.
Kabanov et al. (2020)
4 other articles

1 mention without citation

Computational-Driven Epitope Verification and Affinity Maturation of TLR4-Targeting Antibodies.
Ahmad et al. (2021)