Assemblies
Assembly Name:
20S Proteasome complex
Multimeric state:
hetero 28-mer
Accessible surface area:
214655.31 Å2
Buried surface area:
110825.12 Å2
Dissociation area:
5,660.51
Å2
Dissociation energy (ΔGdiss):
51.21
kcal/mol
Dissociation entropy (TΔSdiss):
16.14
kcal/mol
Symmetry number:
2
PDBe Complex ID:
PDB-CPX-127173
Macromolecules
Chains: A, O
Length: 244 amino acids
Theoretical weight: 27.19 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 244 amino acids
Theoretical weight: 27.19 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P60900 (Residues: 2-245; Coverage: 99%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome subunit alpha6
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
Chains: B, P
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 233 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P25787 (Residues: 2-234; Coverage: 100%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
Chains: C, Q
Length: 250 amino acids
Theoretical weight: 28.12 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 250 amino acids
Theoretical weight: 28.12 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P25789 (Residues: 2-251; Coverage: 96%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
Chains: D, R
Length: 243 amino acids
Theoretical weight: 27.38 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 243 amino acids
Theoretical weight: 27.38 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: O14818 (Residues: 2-244; Coverage: 98%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
Chains: E, S
Length: 234 amino acids
Theoretical weight: 25.57 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 234 amino acids
Theoretical weight: 25.57 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P28066 (Residues: 8-241; Coverage: 97%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
- Proteasome subunit alpha5
Chains: F, T
Length: 238 amino acids
Theoretical weight: 26.73 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 238 amino acids
Theoretical weight: 26.73 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P25786 (Residues: 4-241; Coverage: 91%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
- Proteasome subunit alpha 1
Chains: G, U
Length: 245 amino acids
Theoretical weight: 27.29 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 245 amino acids
Theoretical weight: 27.29 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P25788 (Residues: 2-246; Coverage: 96%)
Pfam:
InterPro:
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome alpha-subunit, N-terminal domain
- Proteasome alpha-type subunit
Chains: H, V
Length: 202 amino acids
Theoretical weight: 21.66 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 202 amino acids
Theoretical weight: 21.66 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P28072 (Residues: 35-236; Coverage: 85%)
Pfam: Proteasome subunit
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Peptidase T1A, proteasome beta-subunit
Chains: I, W
Length: 220 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
UniProt:
Pfam:
InterPro:
Length: 220 amino acids
Theoretical weight: 23.75 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: Q99436 (Residues: 44-263; Coverage: 79%)
Pfam:
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Peptidase T1A, proteasome beta-subunit
- Proteasome beta subunit, C-terminal
Chains: J, X
Length: 204 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 204 amino acids
Theoretical weight: 22.84 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P49720 (Residues: 2-205; Coverage: 100%)
Pfam: Proteasome subunit
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Proteasome beta 3 subunit
Chains: K, Y
Length: 199 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 199 amino acids
Theoretical weight: 22.72 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P49721 (Residues: 1-199; Coverage: 99%)
Pfam: Proteasome subunit
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Proteasome subunit beta 2
Chains: L, Z
Length: 201 amino acids
Theoretical weight: 22.2 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 201 amino acids
Theoretical weight: 22.2 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P28074 (Residues: 60-260; Coverage: 76%)
Pfam: Proteasome subunit
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Peptidase T1A, proteasome beta-subunit
Chains: 1, M
Length: 213 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 213 amino acids
Theoretical weight: 23.58 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P20618 (Residues: 29-241; Coverage: 88%)
Pfam: Proteasome subunit
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
Chains: 2, N
Length: 217 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
UniProt:
Pfam: Proteasome subunit
InterPro:
Length: 217 amino acids
Theoretical weight: 24.14 KDa
Source organism: Homo sapiens
UniProt:
- Canonical: P28070 (Residues: 46-262; Coverage: 82%)
Pfam: Proteasome subunit
InterPro:
- Proteasome B-type subunit
- Nucleophile aminohydrolases, N-terminal
- Proteasome, subunit alpha/beta
- Proteasome beta-type subunit, conserved site
- Proteasome subunit beta 4