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Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitor

X-ray diffraction
2Å resolution
PDB entry 4r1y coloured by chain, front view.
PDB entry 4r1y coloured by chain, side view.
PDB entry 4r1y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Hepatocyte growth factor receptor
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Multimeric state: monomeric
Accessible surface area: 12695.99 Å2
Buried surface area: 1143.98 Å2
Dissociation area: 261.51 Å2
Dissociation energy (ΔGdiss): -3.29 kcal/mol
Dissociation entropy (TΔSdiss): 2.68 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-140186

Macromolecules

Hepatocyte growth factor receptor
Chain: A
Length: 292 amino acids
Theoretical weight: 33.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P08581 (Residues: 1055-1346; Coverage: 21%)
Gene name: MET
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Hepatocyte growth factor receptor in PDB entry 4r1y, assembly 1, front view.
Hepatocyte growth factor receptor in PDB entry 4r1y, assembly 1, side view.
Hepatocyte growth factor receptor in PDB entry 4r1y, assembly 1, top view.
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