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Re-refined Human DNA topoisomerase IIa (ATPase and transducer domains) in complex with ADP and SO4

X-ray diffraction
2.51Å resolution
PDB entry 4r1f coloured by chain, front view.
PDB entry 4r1f coloured by chain, side view.
PDB entry 4r1f coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: DNA topoisomerase 2-alpha
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Multimeric state: homo dimer
Accessible surface area: 32872.42 Å2
Buried surface area: 6870.46 Å2
Dissociation area: 2,276.19 Å2
Dissociation energy (ΔGdiss): 18.1 kcal/mol
Dissociation entropy (TΔSdiss): 14.59 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145812
Assembly 2
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Assembly Name: DNA topoisomerase 2-alpha
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Multimeric state: homo dimer
Accessible surface area: 33535.66 Å2
Buried surface area: 6757.96 Å2
Dissociation area: 2,227.23 Å2
Dissociation energy (ΔGdiss): 17.07 kcal/mol
Dissociation entropy (TΔSdiss): 14.62 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-145812

Macromolecules

DNA topoisomerase 2-alpha
Chains: A, B, C, D
Length: 400 amino acids
Theoretical weight: 45.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11388 (Residues: 29-428; Coverage: 26%)
Gene names: TOP2, TOP2A
Pfam:
InterPro:
CATH:
DNA topoisomerase 2-alpha in PDB entry 4r1f, assembly 1, front view.
DNA topoisomerase 2-alpha in PDB entry 4r1f, assembly 1, side view.
DNA topoisomerase 2-alpha in PDB entry 4r1f, assembly 1, top view.
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