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Crystal structure of the gamma-secretase component Nicastrin

X-ray diffraction
1.95Å resolution
PDB entry 4r12 coloured by chain, front view.
PDB entry 4r12 coloured by chain, side view.
PDB entry 4r12 coloured by chain, top view.
Source organism: Dictyostelium purpureum
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nicastrin
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Multimeric state: monomeric
Accessible surface area: 24088.2 Å2
Buried surface area: 1912.21 Å2
Dissociation area: 42.4 Å2
Dissociation energy (ΔGdiss): 10.05 kcal/mol
Dissociation entropy (TΔSdiss): 0.05 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-123280

Macromolecules

Nicastrin
Chain: A
Length: 593 amino acids
Theoretical weight: 66.73 KDa
Source organism: Dictyostelium purpureum
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: F0ZBA6 (Residues: 19-611; Coverage: 95%)
Gene names: DICPUDRAFT_96800, ncstn
Pfam:
InterPro:
Nicastrin in PDB entry 4r12, assembly 1, front view.
Nicastrin in PDB entry 4r12, assembly 1, side view.
Nicastrin in PDB entry 4r12, assembly 1, top view.
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