X-ray diffraction
1.95Å resolution

Crystal structure of the gamma-secretase component Nicastrin

Source organism: Dictyostelium purpureum
Primary publication:
Crystal structure of the γ-secretase component nicastrin.
Proc Natl Acad Sci U S A 111 13349-54 (2014)
PMID: 25197054

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Nicastrin Chain: A
Molecule details ›
Chain: A
Length: 593 amino acids
Theoretical weight: 66.73 KDa
Source organism: Dictyostelium purpureum
Expression system: Spodoptera frugiperda
  • Canonical: F0ZBA6 (Residues: 19-611; Coverage: 95%)
Gene names: DICPUDRAFT_96800, ncstn
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P41212
Unit cell:
a: 65.584Å b: 65.584Å c: 344.475Å
α: 90° β: 90° γ: 90°
R R work R free
0.181 0.179 0.206
Expression system: Spodoptera frugiperda