› 4r0z

X-ray diffraction
2Å resolution

A conserved phosphorylation switch controls the interaction between cadherin and beta-catenin in vitro and in vivo

Released:
DOI: 10.2210/pdb4r0z/pdb
PDB entry 4r0z coloured by chain, front view.
PDB entry 4r0z coloured by chain, side view.
PDB entry 4r0z coloured by chain, top view.
Source organism: Caenorhabditis elegans
Primary publication:
A conserved phosphorylation switch controls the interaction between cadherin and β-catenin in vitro and in vivo.
Choi HJ, Loveless T, Lynch AM, Bang I, Hardin J, Weis WI
Dev Cell 33 82-93 (2015)
PMID: 25850673

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129187 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-catenin-like protein hmp-2 Chain: A
Molecule details ›
Chain: A
Length: 629 amino acids
Theoretical weight: 68.97 KDa
Source organism: Caenorhabditis elegans
Expression system: Escherichia coli
UniProt:
  • Canonical: O44326 (Residues: 53-678; Coverage: 92%)
Gene names: K05C4.6, hmp-2
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
Ligand FMT 3 x FMT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: C2
Unit cell:
a: 165.225Å b: 38.972Å c: 101.128Å
α: 90° β: 116.67° γ: 90°
R-values:
R R work R free
0.199 0.196 0.234
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
4 more

2 mentions without citation

Sdy-1 Executes Antitumor Activity in HepG2 and HeLa Cancer Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.
Sun et al. (2022)
1 more