X-ray diffraction
2.42Å resolution

Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 188 amino acids
Theoretical weight: 21.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6
Unit cell:
a: 147.954Å b: 147.954Å c: 36.122Å
α: 90° β: 90° γ: 120°
R R work R free
0.185 0.183 0.229
Expression system: Escherichia coli