› 4qxq

X-ray diffraction
2.42Å resolution

Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA

Released:
DOI: 10.2210/pdb4qxq/pdb
PDB 4qxq coloured by chain and viewed from the front.
PDB 4qxq coloured by chain and viewed from the side.
PDB 4qxq coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ
Cell Rep (2014)
PMID: 25199835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 188 amino acids
Theoretical weight: 21.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 1YE 2 x 1YE
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6
Unit cell:
a: 147.954Å b: 147.954Å c: 36.122Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.185 0.183 0.229
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Garland et al. (2022)
10 more

3 mentions without citation

Host-pathogen protein-nucleic acid interactions: A comprehensive review.
Jain et al. (2022)
2 more