› 4qxo

X-ray diffraction
1.88Å resolution

Crystal structure of hSTING(group2) in complex with DMXAA

Released:
DOI: 10.2210/pdb4qxo/pdb
PDB 4qxo coloured by chain and viewed from the front.
PDB 4qxo coloured by chain and viewed from the side.
PDB 4qxo coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Gao P, Zillinger T, Wang W, Ascano M, Dai P, Hartmann G, Tuschl T, Deng L, Barchet W, Patel DJ
Cell Rep (2014)
PMID: 25199835

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chain: A
Molecule details ›
Chain: A
Length: 188 amino acids
Theoretical weight: 21.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86WV6 (Residues: 155-341; Coverage: 49%)
Gene names: ERIS, MITA, STING, STING1, TMEM173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 1YE 1 x 1YE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6122
Unit cell:
a: 62.921Å b: 62.921Å c: 196.054Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.176 0.174 0.218
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.
Garland et al. (2022)
10 more

3 mentions without citation

Host-pathogen protein-nucleic acid interactions: A comprehensive review.
Jain et al. (2022)
2 more