Structure analysis

Crystal Structure of RON Sema-PSI-IPT1 extracellular domains in complex with MSP beta-chain

X-ray diffraction
3Å resolution
Source organism: Homo sapiens
Assembly composition:
Non-polymer only dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

Assemblies

Assembly 1
Download    3D Visualisation
Multimeric state: Non-polymer only dimer
Accessible surface area: 37300 Å2
Buried surface area: 2400 Å2
Dissociation area: 900 Å2
Dissociation energy (ΔGdiss): -6 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): 8 kcal/mol
Symmetry number: 1
Assembly 2 (preferred)
Download    3D Visualisation
Multimeric state: Non-polymer only dimer
Accessible surface area: 37000 Å2
Buried surface area: 2500 Å2
Dissociation area: 850 Å2
Dissociation energy (ΔGdiss): -6 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): 10 kcal/mol
Symmetry number: 1

Macromolecules

Chains: A, B
Length: 669 amino acids
Theoretical weight: 71.99 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q04912 (Residues: 25-683; Coverage: 48%)
  • Best match: Q04912-3 (Residues: 25-474)
Gene names: MST1R, PTK8, RON
Pfam:
InterPro:
CATH: YVTN repeat-like/Quinoprotein amine dehydrogenase

Search similar proteins

Chains: C, D
Length: 253 amino acids
Theoretical weight: 28.34 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P26927 (Residues: 465-711; Coverage: 36%)
Gene names: D3F15S2, DNF15S2, HGFL, MST1
Pfam: Trypsin
InterPro:
CATH: Trypsin-like serine proteases

Search similar proteins