› 4qt8

X-ray diffraction
3Å resolution

Crystal Structure of RON Sema-PSI-IPT1 extracellular domains in complex with MSP beta-chain

Released:
DOI: 10.2210/pdb4qt8/pdb
PDB entry 4qt8 coloured by chain, front view.
PDB entry 4qt8 coloured by chain, side view.
PDB entry 4qt8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the binding specificity of human Recepteur d'Origine Nantais (RON) receptor tyrosine kinase to macrophage-stimulating protein.
Chao KL, Gorlatova NV, Eisenstein E, Herzberg O
J Biol Chem 289 29948-60 (2014)
PMID: 25193665

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150886 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (4 distinct):
Macrophage-stimulating protein receptor beta chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 669 amino acids
Theoretical weight: 71.99 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: Q04912 (Residues: 25-683; Coverage: 48%)
Gene names: MST1R, PTK8, RON
Sequence domains:
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Hepatocyte growth factor-like protein beta chain Chains: C, D
Molecule details ›
Chains: C, D
Length: 253 amino acids
Theoretical weight: 28.34 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: P26927 (Residues: 465-711; Coverage: 36%)
Gene names: D3F15S2, DNF15S2, HGFL, MST1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 106.585Å b: 63.775Å c: 146.049Å
α: 90° β: 90.08° γ: 90°
R-values:
R R work R free
0.237 0.234 0.291
Expression system: Drosophila melanogaster

Quick links

Citations

2 review citations

Strategies of targeting the extracellular domain of RON tyrosine kinase receptor for cancer therapy and drug delivery.
Zarei et al. (2016)
1 more

5 mentions without citation

Genetic Basis of Common Human Disease: Insight into the Role of Missense SNPs from Genome-Wide Association Studies.
Pal et al. (2015)
4 more