PDBe 4qsy

X-ray diffraction
2.1Å resolution

SHP2 SH2 domain in complex with GAB1 peptide

Released:
Source organism: Homo sapiens
Entry authors: Gogl G, Remenyi A

Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tyrosine-protein phosphatase non-receptor type 11 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q06124 (Residues: 1-106; Coverage: 18%)
Gene names: PTP2C, PTPN11, SHPTP2
Sequence domains: SH2 domain
Structure domains: SH2 domain
GRB2-associated-binding protein 1 Chain: B
Molecule details ›
Chain: B
Length: 13 amino acids
Theoretical weight: 1.6 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13480 (Residues: 621-633; Coverage: 2%)
Gene name: GAB1

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P43212
Unit cell:
a: 61.78Å b: 61.78Å c: 74.19Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.2 0.229
Expression systems:
  • Escherichia coli
  • Not provided