PDBe 4qrr

X-ray diffraction
3Å resolution

Crystal Structure of HLA B*3501-IPS in complex with a Delta-Beta TCR, clone 12 TCR

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero pentamer (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
HLA class I histocompatibility antigen, B-35 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: P30685 (Residues: 25-300)
Gene names: HLA-B, HLAB
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Best match: P61769 (Residues: 21-119)
Gene names: B2M, CDABP0092, HDCMA22P
clone12 TCR beta chain Chain: D
Molecule details ›
Chain: D
Length: 206 amino acids
Theoretical weight: 22.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
clone12 TCR alpha chain Chain: E
Molecule details ›
Chain: E
Length: 241 amino acids
Theoretical weight: 27.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
65 kDa phosphoprotein Chain: P
Molecule details ›
Chain: P
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Human herpesvirus 5 strain Towne
Expression system: Not provided
UniProt:
  • Best match: P18139 (Residues: 113-121)
Gene name: UL83

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: C2221
Unit cell:
a: 65.956Å b: 192.149Å c: 162.625Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.21 0.258
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided