› 4qq6

X-ray diffraction
1.75Å resolution

Crystal Structure of tudor domain of SMN1 in complex with a small organic molecule

Released:
DOI: 10.2210/pdb4qq6/pdb
PDB entry 4qq6 coloured by chain, front view.
PDB entry 4qq6 coloured by chain, side view.
PDB entry 4qq6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II.
Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J
Nat Commun 13 5453 (2022)
PMID: 36114190

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172535 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Survival motor neuron protein Chain: A
Molecule details ›
Chain: A
Length: 67 amino acids
Theoretical weight: 7.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16637 (Residues: 82-147; Coverage: 22%)
Gene names: SMN, SMN1, SMN2, SMNC, SMNT
Sequence domains: Survival motor neuron protein (SMN), Tudor domain
Structure domains: SH3 type barrels.

Ligands and Environments

2 bound ligands:
Ligand UNX 3 x UNX
Ligand 36X 1 x 36X
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P65
Unit cell:
a: 27.789Å b: 27.789Å c: 112.817Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.173 0.165 0.242
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Tudor-dimethylarginine interactions: the condensed version.
Šimčíková et al. (2023)
3 other articles

3 mentions without citation

How do SMA-linked mutations of SMN1 lead to structural/functional deficiency of the SMA protein?
Li W. (2017)
2 more