X-ray diffraction
1.8Å resolution

Crystal structure of Jak3 complexed to N-[3-(6-Phenylamino-pyrazin-2-yl)-3H-benzoimidazol-5-yl]-acrylamide


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase JAK3 Chains: A, C
Molecule details ›
Chains: A, C
Length: 293 amino acids
Theoretical weight: 33.3 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P52333 (Residues: 811-1103; Coverage: 26%)
Gene name: JAK3
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 79.511Å b: 43.877Å c: 81.695Å
α: 90° β: 115.26° γ: 90°
R R work R free
0.21 0.207 0.251
Expression system: Spodoptera frugiperda