4qp4

X-ray diffraction
2.2Å resolution

Crystal Structure of ERK2 in complex with N-cyclohexyl-9H-purin-6-amine

Released:
Source organism: Homo sapiens
Entry authors: Yin J, Wang W

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 369 amino acids
Theoretical weight: 42.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P28482 (Residues: 1-360; Coverage: 100%)
Gene names: ERK2, MAPK1, PRKM1, PRKM2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P21
Unit cell:
a: 59.428Å b: 67.229Å c: 86.997Å
α: 90° β: 102.21° γ: 90°
R-values:
R R work R free
0.189 0.187 0.235
Expression system: Escherichia coli