4qn6

X-ray diffraction
1.94Å resolution

Crystal structure of Neuraminidase N6 complexed with Laninamivir

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Neuraminidase Chains: A, B
Molecule details ›
Chains: A, B
Length: 391 amino acids
Theoretical weight: 43.19 KDa
Source organism: Influenza A virus (A/chicken/Nanchang/7-010/2000(H3N6))
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q2FCL6 (Residues: 80-470; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P4212
Unit cell:
a: 137.919Å b: 137.919Å c: 148.797Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.146 0.145 0.161
Expression system: Spodoptera frugiperda