Structure analysis

MST3 in complex with SARACATINIB

X-ray diffraction
1.882Å resolution
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
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Multimeric state: monomeric
Accessible surface area: 14200 Å2
Buried surface area: 1000 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): -4 kcal/mol
Dissociation entropy (TΔSdiss): 6 kcal/mol
Interface energy (ΔGint): -1 kcal/mol
Symmetry number: 1

Macromolecules

Chain: A
Length: 310 amino acids
Theoretical weight: 35.02 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9Y6E0 (Residues: 10-315; Coverage: 68%)
  • Best match: Q9Y6E0-2 (Residues: 1-303)
Gene names: MST3, STK24, STK3
Pfam: Protein kinase domain
InterPro:
CATH:

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