› 4qmj

X-ray diffraction
2.5Å resolution

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

Released:
DOI: 10.2210/pdb4qmj/pdb
PDB 4qmj coloured by chain and viewed from the front.
PDB 4qmj coloured by chain and viewed from the side.
PDB 4qmj coloured by chain and viewed from the top.
Source organism: Homo sapiens
Primary publication:
The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Fox JC, Howard AE, Currie JD, Rogers SL, Slep KC
Mol Biol Cell 25 2375-92 (2014)
PMID: 24966168

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytoskeleton-associated protein 5 Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 27.11 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14008 (Residues: 846-1081; Coverage: 12%)
Gene names: CKAP5, KIAA0097
Sequence domains: CLASP N terminal
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 8 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P43212
Unit cell:
a: 79.125Å b: 79.125Å c: 68.499Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.208 0.276
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Control of microtubule organization and dynamics: two ends in the limelight.
Akhmanova et al. (2015)
2 more

1 mention without citation

The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array.
Fox et al. (2014)