4qkd

X-ray diffraction
1.35Å resolution

Crystal structure of human ALKBH7 in complex with alpha-ketoglutarate and Mn(II)

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 200 amino acids
Theoretical weight: 22.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BT30 (Residues: 17-215; Coverage: 90%)
Gene names: ABH7, ALKBH7, SPATA11, UNQ6002/PRO34564
Sequence domains: 2OG-Fe(II) oxygenase superfamily
Structure domains: Alpha-ketoglutarate-dependent dioxygenase AlkB-like

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 66.426Å b: 82.048Å c: 66.414Å
α: 90° β: 120.03° γ: 90°
R-values:
R R work R free
0.146 0.146 0.163
Expression system: Escherichia coli